The test will allow vets to target the use of preventative medication.
Researchers at Washington State University, supported by the Scottish Deerhound Club of America, have developed a new genetic test that can identify dogs at risk of a condition known as delayed postoperative haemorrhage (DEPOH). The disorder can result in excessive bleeding and bruising in the hours and days after major surgery.
The test was developed following a study of 269 privately owned deerhounds. The dogs were evaluated with an objective of identifying genes associated with DEPOH.
The researchers used genome-wide association analysis to identify a single region on chromosome 9 that contained 40 candidate genes. Further screening of the candidate genes was performed and only the DEPOH gene was identified as being directly linked to the pathophysiology of the disorder.
DEPOH is a potentially fatal disorder that can vary in severity from minor bruising to life-threatening haemorrhaging. The condition typically occurs one to four days after major surgery when blood clots begin to break down too soon, in a process called hyperfibrinolysis.
First identified in racing greyhounds in 2007, DEPOH is an important health problem in certain sighthound breeds, including Scottish deerhounds and greyhounds. Following the identification of the DEPOH gene, the mutation has been discovered in additional sighthounds such as Italian greyhounds and salukis, as well as other breeds including golden retrievers and border collies.
Dogs with a mutation of the DEPOH gene are at higher risk than other dogs of developing the condition post surgery. The new test will allow veterinary surgeons to administer antifibrinolytic drugs to those that test positive for the gene before any surgery.
Previously, veterinary surgeons would have had to administer preventative medication indiscriminately, which can be costly and lead to adverse reactions.
Health and genetics commission chair for the Scottish Deerhound Club of America Dr. John Dillberger said: “Now pet owners can test their dog at any time in its life to understand whether it is at risk.
“And if it is, before planning any scheduled or elective surgery, they can make sure the surgeon is aware of it and prepare accordingly. This will help save the lives of pets.”
The study has been published by the Journal of Veterinary Medicine.
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