Researchers identify mutation causing a type of primary glaucoma
A new DNA test for canine glaucoma has been developed at the Animal Health Trust (AHT), after researchers were able to identify the mutation behind primary open angle glaucoma (POAG) in petit basset griffon vendéens.
Glaucoma causes pain and blindness due to reduced drainage from the eye, which results in a build-up of pressure.
Primary glaucoma is an inherited condition divided into two forms - open angle and closed angle glaucoma. For closed angle glaucoma, a screening technique called gonioscopy is available to identify at-risk dogs.
The test for POAG has been developed at the AHT's Kennel Club Genetics Centre, following several years of research using DNA samples provided by owners and breeders.
Currently, the petit basset griffon vendéen is the only UK breed that is certified under the BVA/KC/ISDS Eye Scheme for POAG.
Dr Cathryn Mellersh, head of the genetics centre at AHT, said: "As there is no clinical test available to screen these dogs for POAG prior to the onset of the disease, it has been challenging for breeders to control.
"Now, any petit basset griffon vendéen can have the non-invasive DNA test, collected via a simple cheek swab, giving the owner peace of mind about both the dog’s eye health and if it is a carrier of the genetic mutation.
"Hopefully, with responsible DNA testing and breeding, we will be able to eradicate this painful and blinding condition from the petit basset griffon vendéen population."
Going forward, the centre plans to explore the genetics behind closed angle glaucoma in dogs, which affects a larger number of breeds.
The new test has been welcomed by Gavin Robertson, who is chairman of the Basset Griffon Vandeen (BGV) Club and the owner of the 2013 Crufts best in show winner, a petit basset griffon vendéen called Jilly.
"Through years of hard work, hundreds of eye tests and the submission of DNA the BGV Club are absolutely delighted that Dr Cathryn Mellersh and her team at the Animal Health Trust have identified and carried out validation experiments on the DNA responsible for POAG in the petit basset griffon vendéen," he commented.
The test will be available from the AHT DNA testing service from March 5, 2015 at a full cost of £48. A limited number of £6 off discount vouchers will be available from the AHT's stand at Crufts (stand 3-55).
Image © OnEdition, The Kennel Club
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