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Gene-edited chicken cells prevent spread of avian flu
The team stopped the virus from spreading by removing a section of chicken DNA inside laboratory-grown cells.

Findings increase likelihood of producing gene-edited chickens

Scientists at the University of Edinburgh have used gene editing techniques to prevent avian influenza virus spreading in laboratory-grown chicken cells.

Researchers say the findings increase the likelihood of producing gene-edited chickens that are resistant to the disease.

The team stopped the virus from spreading by removing a section of chicken DNA inside laboratory-grown cells. The next step will be to produce chickens with the genetic change.

“This is an important advance that suggests we may be able to use gene-editing techniques to produce chickens that are resistant to bird flu,” said Dr Mike McGrew, of the University of Edinburgh’s Roslin Institute. “We haven’t produced any birds yet and we need to check if the DNA change has any other effects on the bird cells before we can take this next step.”

In the study, scientists targeted a specific molecule inside chicken cells called ANP32A. Researchers at Imperial College London found that influenza viruses hijack this molecule during an infection to help replicate themselves.

Together with scientists at the University of Edinburgh’s Roslin Institute, the researchers then used gene-editing techniques to delete the section of DNA responsible for producing ANP32A. They found that the avian flu virus was not able to grow inside cells with the genetic change.

“Avian influenza resistance in broiler production is of global significance and this research is an important step toward that goal," commented Rachel Hawken of Cobb-Vantress, which provided the PhD student funding for the project.

"It is exciting for Cobb to be a part of exploring new technologies that could be used to advance poultry breeding in the future.”

 

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AWF Student Grant open for submissions

News Story 1
 Applications are open for the Animal Welfare Foundation (AWF) Student Grant Scheme for innovative research projects designed to impact animal welfare.

Undergraduate and postgraduate students of veterinary science, veterinary nursing, agriculture studies and animal welfare are invited to submit their proposals to undertake research projects next year.

Grants are decided based on the project’s innovation, relevance to topical animal welfare issues and ability to contribute towards raising animal welfare standards. For more information visit animalwelfarefoundation.org.uk.  

Click here for more...
News Shorts
SPANA film highlights plight of working animals overseas

Animal welfare charity SPANA (The Society for the Protection of Animals Abroad) has teamed up with Brian Blessed and other famous voices to highlight the plight of working animals overseas.

In a new animated film, the celebrities raise awareness by showing the solidarity of the UK's own working animals on strike. A sniffer dog (Brian Blessed), police horse (Peter Egan) and sheepdog (Deborah Meaden) are shown ignoring their duties and protesting in solidarity with animals in developing countries.

SPANA chef executive Geoffrey Dennis said: "We are so grateful to Deborah, Peter and Brian for lending their voices to our new film, and for speaking up for millions of working animals overseas. SPANA believes that a life of work should not mean a life of suffering, and it is only thanks to people’s generosity and support that we can continue our vital work improving the lives of these animals."